Figure 3.
Age comparison of cartilage matrix protein half-lives. (A) Protein half-lives for all investigated ECM proteins, ordered from the shortest to the longest in 25-wk-old animals and presented in log scale. (B) Individual ECM protein half-life comparison between 25-wk (n = 20) and 90-wk (n = 11) old mice. Protein half-lives were calculated from the equation τ1/2 = ln(2)/k, where k is an individual protein synthesis rate. Data are presented as mean ± 95%CI [d]. “x” symbol indicates undetected deuterium incorporation within the 60-d labeling period. Statistical comparison based on two-tailed Student's t-test with Welch's correction.