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. 2022 Apr 6;12(4):e055706. doi: 10.1136/bmjopen-2021-055706

Table 2.

Characteristics of the study population by HIV and HCV antibody status

Median (IQR) or % HIV−/HCV+
(n=77)
HIV+/HCV+
(n=248)
HIV+/HCV−
(n=868)
HIV−/HCV−
(n=383)
P value
Sociodemographic
Age (years) 56 (49, 60) 56 (53, 60) 49 (43, 54) 47 (41, 54) <0.001
Race/Ethnicity 0.001
 Black 64% 67% 76% 76%
 White 7% 15% 9% 7%
 Hispanic 22% 17% 11% 12%
 Other 7% 2% 4% 5%
Menopause stage <0.001
 Premenopause 16% 7% 33% 44%
 Perimenopause 13% 8% 14% 14%
 Postmenopause 71% 85% 53% 43%
Household income (US$)
 <6000 29% 16% 12% 19% <0.001
 6000–12 000 44% 49% 35% 26%
 12 001–36 000 7% 13% 15% 13%
 >36 000 9% 9% 17% 23%
Education
 Less than high school 43% 39% 31% 32% 0.02
 High school 35% 29% 34% 28%
 More than high school 22% 32% 35% 41%
Lifestyle
Alcohol use <0.001
 None 51% 63% 51% 42%
 Light 27% 25% 40% 42%
 Moderate 4% 3% 3% 4%
 Heavy 18% 8% 6% 12%
Current smoking 71% 54% 35% 42% <0.001
Current marijuana use 30% 26% 20% 27% 0.05
Ever injection drug use 36% 23% 1% 4% <0.001
Metabolic
 BMI (kg/m2) 30 (25, 36) 28 (23, 32) 31 (26, 36) 32 (27, 38) <0.001
 Waist circumference (cm) 99 (88, 115) 97 (86, 108) 99 (89, 111) 100 (88, 113) 0.12
 HOMA-IR 3.2 (1.6, 6.8) 2.48 (1.3, 4.9) 2.1 (1.3, 3.8) 1.8 (1.1, 3.3) <0.001
Liver-related
 AST (U/L) 26 (19, 37) 24 (18, 35) 19 (15, 23) 17 (14, 20) <0.001
 ALT (U/L) 23 (15, 34) 18 (12, 30) 15 (12, 21) 14 (11, 18) <0.001
HIV-related
 Undetectable HIV RNA 69% 72% 0.60
 CD4 current (cells/mm3) 616 (428, 869) 656 (435, 870) 0.35
 CD4 nadir (cells/mm3) 215 (107, 320) 222 (103, 361) 0.95
 History of clinical AIDS 42% 28% <0.001
Current ART 89% 89% 0.81
 NNRTI 30% 29% 0.84
 PI 26% 25% 0.80
 INSTI 44% 48% 0.22
 EI 1.6% 0.8% 0.26

ALT, alanine aminotransferase; AST, aspartate transaminase; BMI, body mass index; EI, entry inhibitor; HCV, hepatitis C virus; HOMA-IR, homeostatic model assessment of insulin resistance; INSTI, integrase strand transfer inhibitor; NNRTI, non-nucleoside reverse transcriptase inhibitor; PI, protease inhibitor.