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. 2022 Apr 6;12(4):e055706. doi: 10.1136/bmjopen-2021-055706

Table 3.

Independent associations of clinical and demographic characteristics with CAP and LS*

CAP difference (dB/m) (95% CI)† P value LS
% change (95% CI)‡
P value
Infection status (ref=HIV−/HCV−)
 HIV+/HCV− 1.1 (−5.3 to 7.5) 0.74 4.4% (−1.1% to 10.3%) 0.12
 HIV+/HCV+ −9.2 (−18.2 to –0.3) 0.04 33.4% (23.5% to 44.1%) <0.001
 HIV−/HCV+ −10.4 (−23.8 to 3.1) 0.13 43.2% (27.8% to 60.4%) <0.001
Age (per 10 years) 2.4 (−2.0 to 6.9) 0.29 4.4% (0.4% to 8.4%) 0.03
Race/Ethnicity (ref=white non-Hispanic)
 Black −6.1 (−14.2 to 2.1) 0.14 2.8% (−4.0% to 10.1%) 0.43
 Hispanic −3.1 (−12.6 to 6.4) 0.52 3.1% (−5.0% to 11.7%) 0.47
 Other 2.9 (−8.2 to 14.0) 0.61 2.5% (−6.7% to 12.7%) 0.60
Waist circumference (per 10 cm) 17.8 (16.2 to 19.4) <0.001 5.0% (3.3% to 6.6%) <0.001
HOMA-IR (per doubling) 1.2 (0.8 to 1.6) <0.001 0.3% (−0.1% to 0.7%) 0.11
CAP (per 10 dB/m) 0.6% (0.1% to 1.0%) 0.01

*All variables shown in the table are included in a single multiple linear regression model (one model for CAP and one for LS). Also adjusted for alcohol use, smoking status and menopause stage (parameter estimates not shown).

†N=1543.

‡N=1576.

CAP, controlled attenuation parameter; HCV, hepatitis C virus; HOMA-IR, homeostatic model assessment of insulin resistance; LS, liver stiffness.