Table 3.
Independent associations of clinical and demographic characteristics with CAP and LS*
CAP difference (dB/m) (95% CI)† | P value | LS % change (95% CI)‡ |
P value | |
Infection status (ref=HIV−/HCV−) | ||||
HIV+/HCV− | 1.1 (−5.3 to 7.5) | 0.74 | 4.4% (−1.1% to 10.3%) | 0.12 |
HIV+/HCV+ | −9.2 (−18.2 to –0.3) | 0.04 | 33.4% (23.5% to 44.1%) | <0.001 |
HIV−/HCV+ | −10.4 (−23.8 to 3.1) | 0.13 | 43.2% (27.8% to 60.4%) | <0.001 |
Age (per 10 years) | 2.4 (−2.0 to 6.9) | 0.29 | 4.4% (0.4% to 8.4%) | 0.03 |
Race/Ethnicity (ref=white non-Hispanic) | ||||
Black | −6.1 (−14.2 to 2.1) | 0.14 | 2.8% (−4.0% to 10.1%) | 0.43 |
Hispanic | −3.1 (−12.6 to 6.4) | 0.52 | 3.1% (−5.0% to 11.7%) | 0.47 |
Other | 2.9 (−8.2 to 14.0) | 0.61 | 2.5% (−6.7% to 12.7%) | 0.60 |
Waist circumference (per 10 cm) | 17.8 (16.2 to 19.4) | <0.001 | 5.0% (3.3% to 6.6%) | <0.001 |
HOMA-IR (per doubling) | 1.2 (0.8 to 1.6) | <0.001 | 0.3% (−0.1% to 0.7%) | 0.11 |
CAP (per 10 dB/m) | 0.6% (0.1% to 1.0%) | 0.01 |
*All variables shown in the table are included in a single multiple linear regression model (one model for CAP and one for LS). Also adjusted for alcohol use, smoking status and menopause stage (parameter estimates not shown).
†N=1543.
‡N=1576.
CAP, controlled attenuation parameter; HCV, hepatitis C virus; HOMA-IR, homeostatic model assessment of insulin resistance; LS, liver stiffness.