Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 8;10:goac009. doi: 10.1093/gastro/goac009

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022. Published by Oxford University Press and Sixth Affiliated Hospital of Sun Yat-sen University

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 2. — Regulation of gut microbiota–bile acid–farnesoid X receptor (FXR) axis to improve type 2 diabetes. Metformin reduces the abundance of B. fragilis and inhibits bile salt hydrolase (BSH) activity. These changes can further increase levels of GUDCA (endogenous FXR antagonists) and suppress the FXR signaling. It shows beneficial effects on metabolic diseases dependent on intestinal FXR inhibition.