Table 4.

Effects of circRNAs in chronic myeloid leukemia

circRNA name and ID	Expression	Gene	Effects	miRNA that the circRNA sponges or targets	Does the circRNA promote or demote AML formation?	Can it be used as a biomarker or prognostic tool?	References
circBA9.3 (fusion circRNA)	Upregulated	BCR-ABL1	Promote cell proliferation, causes TKI resistance due to increased ABL1 expression, causes drug resistance and inhibits apoptosis.	None	Promotes CML formation.	It can be targeted to be used as a therapeutic target.	[45,131]
hsa_circ_0080145; hsa_circ_0024002; hsa_circ_0037781	Upregulated		Sponges the miRNAs involved in inhibiting vascular inflammation, thereby promoting CML pathogenesis.	miR-16, miR-181a, miR-29b	Promotes CML proliferation.	Since hsa_circ_008014 sponges miR-29b it has potential for being a potential prognostic and therapeutic target for curing CML cell lines.	[137]