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. 2022 Apr 7;13:1897. doi: 10.1038/s41467-022-29499-8

Fig. 6. FGF21-dependent and independent changes in molecular endpoints in the adipose tissue at 22 months of age.

Fig. 6

a Serum adiponectin collected at 22 months of age (n = 8–10 mice/group; geno*diet p = 0.009). b Thermogenic gene expression in inguinal white adipose tissue (iWAT) collected at sacrifice at 22 months of age (n = 8–10 mice/group; geno*diet Ucp1 p = 0.0023, Cidea p = 0.0065). c Energy metabolism gene expression in iWAT at 22 months of age (n = 8–10 mice/group; Srebp1 diet p = 0.01 geno*diet p = 0.1876, Acc1 geno*diet p = 0.002, Fas geno*diet p = 0.002, Scd1 geno*diet p = 0.1388, Pparg geno*diet p = 0.6344, Ppara geno*diet p = 0.01, Pgc1a geno*diet p = 0.02). d Expression of thermogenic markers within BAT (n = 3–10 mice/group; Ucp1 geno*diet p = 0.6124, Cidea geno*diet p = 0.5739, Dio2 diet p = 0.05 geno*diet p = 0.99, Pgc1a diet p = 0.007 geno*diet p = 0.37, Prdm16 geno p = 0.0079 geno*diet p = 0.37). e Expression of inflammatory markers within visceral adipose tissue (n = 8–10 mice/group; Adgre geno*diet p = 0.009, Cd68 p = 0.006, Arg1 geno*diet p = 0.01, Itgam diet p = 0.002 geno p = 0.03 geno*diet p = 0.14, IL1b geno*diet p = 0.9, IL6 geno*diet p = 0.67). Statistical analyses were conducted using two-way ANOVA. All values are mean ± SEM, with significant main effects of diet or posthoc comparison within the diet*genotype interaction noted as *p < 0.05, #p < 0.10 compared with respective control. Source data are provided as a Source Data file.