Fig. 3. Blocking MOXD1 inhibits self-renewal and tumor growth of GBM.

A One thousand cells were tiled in a six-well plate and the planar cloning assay was used to detect the self-renewal ability in MOXD1 knockdown cells. B Statistics of cell self-renewal after culturing for 7 days. C, D Soft agar assays was used to detect the self-renewal ability in MOXD1 knockdown cells. E Statistics of cell spheroidizing ability after culturing for 20 days. F HE staining was used to detect tumorigenesis of GBM intracranial injection in mice. G Survival curve of mice injected intracranially with MOXD1 knockdown cells.