Table 4.

Box-Benkhen experimental design and observed responses.

Run	HAE conditions			Experimental values
	Temperature (oC)	Solid to liquid ratio (g/mL)	Time (min)	EY (w/w %)	TPC (mg GAE/g d.w)
1	35.00	1:35	100.00	20.11	60.02
2	55.00	1:35	100.00	20.45	22.12
3	55.00	1:35	200.00	26.31	29.11
4	55.00	1:20	150.00	21.71	23.34
5	45.00	1:35	150.00	17.02	21.10
6	35.00	1:20	150.00	16.45	18.21
7	45.00	1:35	150.00	16.08	24.23
8	45.00	1:50	200.00	14.12	29.42
9	45.00	1:50	100.00	10.53	53.32
10	45.00	1:35	150.00	16.17	20.54
11	35.00	1:50	150.00	13.34	75.22
12	55.00	1:50	150.00	16.13	12.18
13	45.00	1:35	150.00	16.82	22.18
14	35.00	1:35	200.00	20.06	50.22
15	45.00	1:20	200.00	19.23	17.43
16	45.00	1:35	150.00	16.91	18.28
17	45.00	1:20	100.00	17.11	20.78