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. 2022 Feb 28;106(4):1227–1236. doi: 10.4269/ajtmh.21-1084

Figure 4.

Figure 4.

Intravenous (IV) administration of glycolipid adjuvant 7DW8-5 induces a systemic and potent interferon (IFNγ) and interleukin 4 (IL-4) spike. (A) Quantification of IFNγ (Left) and IL-4 (Right) in mouse blood plasma induced by 7DW8-5 injection over time measured by ELISA. Kruskal–Wallis with Dunn’s multiple comparisons test, baseline vs. all other groups. 95% CI of mean for 12 hpi: IFNγ 8,792–16,077, IL-4 40.5–84.9 pg/mL. (B) Results of anti-CD1d blocking studies after administration of 7DW8-5. Multiple unpaired t tests. 95% CI of mean for 12 hpi: Isotype control 9434–15941, anti-CD1d 4458–9238 pg/mL. Error bars represent SD of mean of N = 10 mice across two experiments. ND = not detected; ns = P > 0.05. ** P < 0.005, **** P < 0.0001.