Figure 6.

Plasmodium yoelii (Py) cryopreserved radiation attenuated sporozoite (cryo-RAS) trap dose can be reduced by the co-administration of 7DW8-5. (A) Experimental design of prime-and-trap studies. (B) Results of protection studies after challenge with 1 × 10³ wild-type purified Py sporozoite (spz) administered 4 weeks (Day 56) after trapping. N = 10–20 mice across two to four experiments. Fractions above bars indicate the number of animals protected out of total group size. Protection was assessed with thin blood smears on Days 3–14 post-challenge. Fisher Exact Test: 2 × 10⁴ cryo-RAS vs. all other groups and 5 × 10³ ggCSP+(cryo-RAS+7DW8-5) vs. all other groups. ns = P > 0.05. * P < 0.05, *** P < 0.0005.