Table 2.
GO biological process, cellular component (CC), and molecular function (MF) enriched in chemoresistant relapse and chemosensitive primary samples.
| GO ID | Description | Ontology | Count | P.adj value |
|---|---|---|---|---|
| Upregulated GO terms in chemoresistant relapse samples | ||||
| GO:0008544 | Epidermis development | BP | 64 | 2.09E-07 |
| GO:0032496 | Response to lipopolysaccharide | BP | 48 | 3.86E-06 |
| GO:0043588 | Skin development | BP | 56 | 3.86E-06 |
| GO:0002237 | Response to molecule of bacterial origin | BP | 48 | 9.33E-06 |
| GO:0009913 | Epidermal cell differentiation | BP | 48 | 2.97E-05 |
| GO:0071216 | Cellular response to biotic stimulus | BP | 35 | 1.59E-04 |
| GO:0071496 | Cellular response to external stimulus | BP | 44 | 1.59E-04 |
| GO:0007156 | Homophilic cell adhesion via plasma membrane adhesion molecules | BP | 28 | 1.59E-04 |
| GO:0098742 | Cell-cell adhesion via plasma-membrane adhesion molecules | BP | 38 | 1.59E-04 |
| GO:0048732 | Gland development | BP | 52 | 1.59E-04 |
| GO:0048018 | Receptor ligand activity | MF | 59 | 5.43E-05 |
| GO:0030546 | Signaling receptor activator activity | MF | 59 | 5.43E-05 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | MF | 49 | 3.37E-03 |
| GO:0001216 | DNA-binding transcription activator activity | MF | 49 | 3.37E-03 |
| GO:0005520 | Insulin-like growth factor binding | MF | 9 | 3.92E-03 |
| GO:0046873 | Metal ion transmembrane transporter activity | MF | 48 | 4.40E-03 |
| GO:0005125 | Cytokine activity | MF | 29 | 5.58E-03 |
| GO:0033549 | MAP kinase phosphatase activity | MF | 6 | 1.54E-02 |
| GO:0022836 | Gated channel activity | MF | 37 | 3.07E-02 |
| GO:0005216 | Ion channel activity | MF | 44 | 3.26E-02 |
| GO:0016755 | Transferase activity, transferring amino-acyl groups | MF | 6 | 3.56E-02 |
| GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity | MF | 5 | 4.78E-02 |
| Downregulated GO terms in chemoresistant relapse samples | ||||
| GO:0030198 | Extracellular matrix organization | BP | 73 | 3.42E-17 |
| GO:0043062 | Extracellular structure organization | BP | 73 | 3.42E-17 |
| GO:0061448 | Connective tissue development | BP | 48 | 9.05E-09 |
| GO:0051216 | Cartilage development | BP | 39 | 1.07E-07 |
| GO:0030199 | Collagen fibril organization | BP | 18 | 6.87E-07 |
| GO:0002062 | Chondrocyte differentiation | BP | 27 | 1.44E-06 |
| GO:0042110 | T cell activation | BP | 60 | 3.78E-06 |
| GO:0003341 | Cilium movement | BP | 19 | 6.96E-06 |
| GO:0001503 | Ossification | BP | 51 | 5.40E-05 |
| GO:0061035 | Regulation of cartilage development | BP | 18 | 5.40E-05 |
| GO:0062023 | Collagen-containing extracellular matrix | CC | 88 | 9.64E-25 |
| GO:0005581 | Collagen trimer | CC | 33 | 1.66E-16 |
| GO:0009897 | External side of plasma membrane | CC | 59 | 3.94E-09 |
| GO:0005583 | Fibrillar collagen trimer | CC | 9 | 4.02E-08 |
| GO:0098643 | Banded collagen fibril | CC | 9 | 4.02E-08 |
| GO:0005604 | Basement membrane | CC | 22 | 1.80E-06 |
| GO:0098644 | Complex of collagen trimers | CC | 10 | 1.91E-06 |
| GO:0005788 | Endoplasmic reticulum lumen | CC | 44 | 2.61E-06 |
| GO:0031514 | Motile cilium | CC | 28 | 1.04E-04 |
| GO:0005930 | Axoneme | CC | 22 | 1.26E-04 |
| GO:0005201 | Extracellular matrix structural constituent | MF | 49 | 1.91E-18 |
| GO:0030020 | Extracellular matrix structural constituent conferring tensile strength | MF | 19 | 2.29E-10 |
| GO:0019838 | Growth factor binding | MF | 30 | 2.25E-07 |
| GO:0005518 | Collagen binding | MF | 19 | 2.44E-06 |
| GO:0048407 | Platelet-derived growth factor binding | MF | 8 | 4.57E-06 |
| GO:0019956 | Chemokine binding | MF | 12 | 2.69E-05 |
| GO:0019957 | C-C chemokine binding | MF | 10 | 7.71E-05 |
| GO:0016493 | C-C chemokine receptor activity | MF | 9 | 4.64E-04 |
| GO:0005178 | Integrin binding | MF | 23 | 4.77E-04 |
| GO:0048018 | Receptor ligand activity | MF | 55 | 5.66E-04 |