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. 2022 Apr 7;22:144. doi: 10.1186/s12935-022-02558-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Interaction network and biological process analysis of hub DEGs. a Gene modules of hub DEGs. The color layout of the nine hub DEGs changed from yellow to red according to the cytoHubba plugin, indicating their increased importance. b GO enrichment analysis of hub DEGs. Enrichment analysis of hub genes was constructed. The number and names of hub genes involved in the gene ontology. p < 0.05 was considered statistically significant. c Heat map of hub DEGs. The color layout therein from blue to red indicates the expression levels of hub DEGs from down to up