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. Author manuscript; available in PMC: 2022 Apr 8.
Published in final edited form as: J Am Coll Cardiol. 2015 Dec 8;66(22):2522–2533. doi: 10.1016/j.jacc.2015.09.061

FIGURE 1. Custom Array: Primary Data Sources and Bioinformatic Analyses.

FIGURE 1

Approximately one-third of the 1,536 single nucleotide variants (SNVs) were derived from the gene expression-weighted analysis of extreme response genome-wide association studies (GWAS); one-third from the most statistically significant intergenic single nucleotide polymorphisms (SNPs) from the extreme response GWAS; and one-third from the GWAS-informed analyses of gene-coexpression networks, semantic published data networks, or a curated set of SNPs manually selected from the published data.