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. 2022 Apr 7;22:370. doi: 10.1186/s12885-022-09386-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The expression of TIM-1 in cervical tissues and CC cell lines. A The expression of the TIM-1 protein in CIN I, II, and III, respectively. B The expression level of TIM-1 in normal cervical, CIN, adenocarcinoma and squamous carinoma. C The expression level of TIM-1 in normal cervical, CIN, FIGO stages I and FIGO stages II. D The expression level of TIM-1 in normal cervical, CIN, Infiltration depth ≥ 1/2 and Infiltration depth < 1/2. E The expression level of TIM-1 in normal cervical, CIN, lymph metastasis and lymph nonmetastasis. F The expression level of TIM-1 in normal cervical, CIN, nerve invasion and nerve noninvasion. G The expression of TIM-1 in normal cervical, CIN, vascular invasion and vascular noninvasion.RT-qPCR (H) and western blotting analysis (I) of the expression of TIM-1 in three CC cell lines (C-33A, Hela, and SiHa). Data are shown as means ± SD. **P < 0.01 and ***P < 0.001. TIM-1, T-cell immunoglobulin mucin-1; CIN, cervical intraepithelial neoplasia; CC, cervical cancer; HSIL, high grade squamous intraepithelial lesion; LSIL, low grade squamous intraepithelial lesion