TABLE 1.
MTDs of AMB-DOC, hAMB-DOC, and hcAMB-DOC in uninfected micea
| Parameter for toxicityb | MTD (mg of AMB/kg)
|
||
|---|---|---|---|
| AMB-DOC | hAMB-DOC | hcAMB-DOC | |
| Death after treatment | 0.8 | 7 | 7 |
| Impaired renal function | >0.8 | 5 | 5 |
| Impaired liver function | >0.8 | 3 | 3 |
a
Mice were treated i.v. with a single dose. AMB dosages ranged from 0.1 to 1.0 mg/kg in steps of 0.1 mg/kg and from 1 to 9 mg/kg in steps of 1 mg/kg.
b
Toxicity was determined as causing death after treatment or >3-fold increases in the indices for renal function (blood urea nitrogen and serum creatinine) and liver function (aspartate aminotransferase and alanine aminotransferase) compared with those for untreated mice determined 24 h after treatment.