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. 2022 Apr 7;20:45. doi: 10.1186/s12964-022-00861-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — TRIM3 modulates estrogen signaling in breast cancer cells. a and b KEGG analysis of downregulated (left) and upregulated (right) genes in RNA-seq data of TRIM3 siRNA MCF-7 cells. c Volcano plot shows that canonical ER target genes are enriched in downregulated genes in TRIM3 siRNA MCF-7 cells. Threshold P < 0.01 and fold change > 2. d Gene set enrichment analysis (GSEA) shows enrichment of estrogen response genes in TRIM3 siRNA MCF-7 cells. e Heatmap of the correlation between TRIM3 and ER signaling target genes in breast invasive carcinoma (TCGA, PanCancer Atlas). Different colors represent correlation coefficients (in the diagram, red represents a positive correlation, blue represents a negative correlation), and darker colors represent stronger correlations. Asterisks represent levels of significance (***P < 0.001)