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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Neuropharmacology. 2021 Nov 29;205:108907. doi: 10.1016/j.neuropharm.2021.108907

Figure 6. Pioglitazone reduced heat and mechanical hyperalgesia in male and female ZDF rats.

Figure 6.

Values are plotted as the difference between pre-drug baseline values and 1–2 hour post-drug values collected in ZDF and ZL genetic controls after i.p. injection of pioglitazone at doses of 0, 100, 300 mg/kg, with respect to changes from baseline in (A) Hotplate latency, (B) cold plate responses and (C) glucose. Further studies comparing males and females illustrate that 100 mg/kg pioglitazone decreased heat hypersensitivity in (D) male and (E) female ZDF rats. (F) Analysis of the data with Time collapsed across post-injection timepoints illustrates that pioglitazone exerted a similar decrease in heat hypersensitivity in ZDF females and males at 100 mg/kg. 100 mg/kg pioglitazone decreased mechanical hypersensitivity in (G) male and female (H) ZDF rats. (I) Analysis of the data with Time collapsed across post-injection timepoints illustrates that pioglitazone exerted a similar decrease in mechanical hypersensitivity in males and females. Three-way ANOVA and Tukey’s multiple comparisons test for figures 6D–E and 6G–H. Two-way ANOVA and Sidak’s multiple comparisons test for figures 6A–C, 6F and 6I. Symbol: Panels A-C *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001 pre- vs post-injection value; Panels D, E, G, H *p<0.05 ZDF vehicle vs ZDF Pio 100 mg/kg. Panels F and I * P<0.05 vehicle vs Pio 100 mg/kg. Values represent mean ± SEM. N=8–15.