Figure 1.

Locally weighted polynomial regression (LOESS) of adjusted associations of estradiol concentrations with depression and anxiety scores among boys.

Adjusted for age, BMI-for-age z-score, parental education, household income, hemoglobin concentration, awakening time, saliva collection time, and sexual maturation. Each data point represents the adjusted least squares of anxiety or depression score for 150 ranks of ln(estradiol) concentrations. The line represents the locally weighted fitted value, while the blue-grey shaded bands are the 95% confidence intervals across each value of the x axis.