Table 3.
Adjusted associations of sex and adrenal hormones with depression and anxiety scores for girls, overall and stratified by medians of cortisol and testosterone.
| Score difference (β) per 10% increase in hormone level (95% CI) |
|||||
|---|---|---|---|---|---|
| Girls | |||||
| All |
Cortisol |
Testosterone |
|||
| Below Median (0.002 – 0.19 μg/dL) |
Above Median (0.20 – 1.17 μg/dL) |
Below Median (2.01 – 3.49 μg/mL) |
Above Median (3.50 – 4.96 pg/mL) |
||
| Depression (n=259) | |||||
| Testosterone | −0.06 (−0.16, 0.03) | 0.04 (−0.10, 0.17) | −0.19 (−0.35, −0.03) a | - | - |
| DHEA | −0.02 (−0.98, 0.04) | 0.05 (−0.04, 0.134) | −0.12 (−0.22, −0.02) a | −0.03 (−0.14, 0.08) | 0.02 (−0.09, 0.12) |
| Cortisol | 0.25 (−0.15, 0.65) | - | - | 0.94 (0.22, 1.66) a | 0.04 (−0.50, 0.59) |
| Anxiety (n=260) | |||||
| Testosterone | 0.03 (−0.05, 0.12) | 0.02 (−0.14, 0.17) | −0.06 (−0.22, 0.10) | - | - |
| DHEA | −0.03 (−0.09, 0.02) | −0.03 (−0.12, 0.07) | 0.06 (−0.04, 0.16) | 0.04 (−0.08, 0.15) | −0.02 (−0.12, 0.08) |
| Cortisol | 0.01 (−0.42, 0.43) | - | - | 0.50 (−0.30, 1.32) | −0.26 (−0.79, 0.27) |
Adjusted for hemoglobin, saliva time, awakening time, age, BMI-for-age z-score, Tanner score, parental education, and household monthly income.
DHEA = dehydroepiandrosterone
a
p<0.05