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Reagents and conditions: i. For X = H: Et3N, CH2Cl2. For X = -CH3: (a) Et3N, CH2Cl2, (b) LiOH, MeOH, THF, H2O; ii. 8a, HATU, Et3N, DMF, 45 °C; iii. 4N HCl/dioxane; iv. CH3COCl, Et3N, DMF; v. C3H7I, K2CO3, DMF.
