Stuifbergen 2003.

Methods	RCT.
Participants	USA N = 121 (8 dropouts) treatment = 61 (5 drop outs), control = 60 (3 drop outs)
Interventions	Treatment group ‐ 2‐phased MD wellness programme consisting of a lifestyle change phase, followed by telephone calls post completion of programme. Control group ‐ monthly phone call.
Outcomes	ISS, SF36, SRAHP, HPLP‐II, BHPADPS, PRQ85 (part 2), employment
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomisation performed by random number table method.
Allocation concealment (selection bias)	High risk	Allocation concealment not stated.
Blinding of participants and personnel (performance bias) All outcomes	High risk	No blinding of participants and treating personnel.
Blinding of outcome assessment (detection bias) All outcomes	High risk	No blinding of outcome assessors.
Incomplete outcome data (attrition bias) All outcomes	Low risk	Overall 75 dropout.
Selective reporting (reporting bias)	Low risk	All pre‐specified primary and secondary outcomes reported.
Other bias	Unclear risk	ITT was specified but figures were not provided.

ITT = Intention to Treat 
 IVMP = intravenous methylprednisolone 
 MD = Multidisciplinary 
 MS = Multiple sclerosis 
 N = Number 
 OT = Occupational therapy 
 PT = Physiotherapy 
 RCT = Randomised Controlled Trial

CCT Clinical Controlled Trial 
 UK = United Kingdom 
 USA = United States of America