TABLE 1.
Pharmacokinetic parameters of (−) and (+) dOTCa
| Enantiomer | Vss (liters/ 65 kg) | CLt (liters/h/65 kg) | λft1/2 (h) | λst1/2 (h) | λzt1/2 (h) | Cmax (μg/ml/65 kg) | Tmax (h) | CLdf (liters/h/65 kg) | CLds (liters/h/65 kg) | F |
|---|---|---|---|---|---|---|---|---|---|---|
| (+) dOTC | ||||||||||
| Median | 74.7 | 11.7 | 0.21 | 2.49 | 18.0 | 4.7 | 1.4 | 19.3 | 1.63 | 76.3 |
| Mean | 76.6 | 11.6 | 0.29 | 2.56 | 19.2 | 5.1 | 1.2 | 18.2 | 1.68 | 77.2 |
| CV% | 19.2 | 17.3 | 56.6 | 15.7 | 31.5 | 23.7 | 44.6 | 34.5 | 22.8 | 13.6 |
| (−) dOTC | ||||||||||
| Median | 51.7 | 15.4 | 0.19 | 2.03 | 6.80 | 4.2 | 1.3 | 23.6 | 1.58 | 78.2 |
| Mean | 54.8 | 15.3 | 0.28 | 2.15 | 8.92 | 4.4 | 1.2 | 22.5 | 1.56 | 80.7 |
| CV% | 16.7 | 18.6 | 62.7 | 24.4 | 69.9 | 25.8 | 47.8 | 39.5 | 48.9 | 14.6 |
a
λft1/2, fast distributional phase half-life; λst1/2, slow distributional phase half-life; λzt1/2, terminal elimination half-life; Tmax, time to maximum concentration of drug in serum.