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Absorption characteristics of (−) and (+) dOTCa
| Parameter | Phase 1
|
Phase 2
|
Phase 3
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| TLag (h) | ka (h−1) | D% | TLag (h) | ka (h−1) | D% | TLag (h) | ka (h−1) | D% | |
| n | 12 | 12 | 12 | 12 | 12 | 12 | 10 | 10 | 10 |
| Median | 0.40 | 1.03 | 31.4 | 0.77 | 1.68 | 55.9 | 1.99 | 1.50 | 23.6 |
| Mean | 0.36 | 1.80 | 32.7 | 0.95 | 2.82 | 48.8 | 2.41 | 7.25 | 22.2 |
| CV% | 33.2 | 119 | 59.1 | 57.6 | 72.6 | 36.5 | 39.4 | 225 | 41.0 |
