TABLE 4.

P values of pair-wise comparison of fungal burden data for isolate 2 (nikkomycin Z MIC, 4 μg/ml)

Agents compared (mg/kg/dose)	Antigen		Quantitative cultureb
	Lung	Spleen	Lung	Spleen
Control to amphotericin B (2.0)	0.0026	0.0010	<0.0001
Control to itraconazole (75)	NSa	0.0369	<0.0001
Control to nikkomycin Z (100)	0.0041	0.0004
Control to nikkomycin Z (20)	0.0015	0.0038	NS
Control to nikkomycin Z (5)	NS	NS
Amphotericin B (2.0) to itraconazole (75)	NS	NS	<0.0001	0.0002
Amphotericin B (2.0) to nikkomycin Z (100)	NS	NS		NS
Amphotericin B (2.0) to nikkomycin Z (20)	NS	NS	<0.0001	0.0088
Amphotericin B (2.0) to nikkomycin Z (5)	NS	0.0013
Itraconazole (75) to nikkomycin Z (100)	NS	NS		0.0006
Itraconazole (75) to nikkomycin Z (20)	0.0305	NS	0.0078	NS
Itraconazole (75) to nikkomycin Z (5)	NS	NS
Nikkomycin Z (100) to nikkomycin Z (20)	NS	NS		0.0149
Nikkomycin Z (100) to nikkomycin Z (5)	NS	0.0005
Nikkomycin Z (20) to nikkomycin Z (5)	NS	0.0089

^aNS, not significant (P > 0.05). 

^bBlank cells indicate that no comparison was made due to an insufficient number of evaluable samples in the control or nikkomycin Z groups.