FIG. 1.

Effects of drugs on P. carinii f. sp. carinii ATP levels after 24 (left), 48 (center), and 72 (right) h. (A) Inhibitors of squalene synthase CCI 16543 (□) and CCI 14993 (▄). (B) Terbinafine, an inhibitor of squalene epoxidase. (C) Inhibitors of squalene epoxide-lanosterol cyclase GR 90525A (□), GR 193018A (⬒), GR 54985A (▧), UI 8666A (▄), and GR 31149 (▤). (D) Inhibitors of lanosterol demethylase GR 40317A (□) and GR 42539X (▄). (E) AY 9944, an inhibitor of Δ⁸ to Δ⁷ isomerase activity. (F) Amphotericin B, a polyene drug that binds to membrane sterols.