TABLE 1.
Drugs tested for their effects on P. carinii f. sp. carinii
| Targeted activity and drug (source) | Mol wt or formula wt | Structure and/or description |
|---|---|---|
| HMG-CoA reductase | ||
| Lovastatin (Merck) | 404.5 | |
| Simvastatin (Merck) | 418.5 | |
| L-647,318 (Merck) | 422.6 | Prodrug similar to lovastatin and simvastatin |
| L-654,164 (Merck) | 220.5 | Bromo- and chlorinated amine compound; not a statin drug |
| Squalene synthase | ||
| Squalestatin, GR 105155X (Glaxo) | 690.7 | |
| CCI 16543 (Glaxo) | 319.8 | Biphenyl alkylamine derivative |
 |
||
| CCI 14993 (Glaxo) | 439.4 | Naphthalene alkylamine derivative |
 |
||
| Squalene epoxidase | ||
| Terbinafine | 291 | |
 |
||
| Tolnaftate (Sigma) | 307 | |
| Squalene epoxide-lanosterol cyclase | ||
| GR 31149A (Glaxo) | 317.9 | Bis-cyclohexyloxyalkylamine derivative |
| GR 54985A (Glaxo) | 331.9 | Bis-cyclohexyloxyalkylamine derivative |
| GR 90525A (Glaxo) | 267.8 | Phenylcyclohexylamine derivative |
| GR 193018A (Glaxo) | 267.8 | Phenylcyclohexylamine derivative |
| UI 8666A | 145.4 | 3-β-[(Diethylamino)ethoxy]androst-5-en-17-one |
 |
||
| Lanosterol demethylase | ||
| GR 40317A (Glaxo) | 372.2 | Imidazole derivative |
 |
||
| Targeted activity and drug (source) | Mol wt or formula wt | Structure and/or description |
| GR 40665X (Glaxo) | 281.1 | Imidazole derivative |
 |
||
| GR 42539X (Glaxo) | 293.2 | Imidazole derivative |
 |
||
| Fluconazole | 306.2 | |
| GR 71539X (Glaxo) | 343.3 | Triazole derivative |
|
||
| GR 77303X (Glaxo) | 357.4 | Triazole derivative |
| Δ8 to Δ7 isomerase (AY 9944 [Ayerst]) | 495 | |
 |
||
| SAM:sterol methyltransferases | ||
| 24(25)-Epiminolanosterol (E. J. Parish) | 440 | |
| 24-Bromolanosterol (E. J. Parish) | 504 | |
| 24-Iodolanosterol (E. J. Parish) | 542 | |
| Sinefungin (Sigma) | 381.4 | SAM analog |
| Membrane sterol (amphotericin B) | 924.1 | Polyene antibiotic |
 |