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. 2021 Nov 2;4(4):946–964. doi: 10.20517/cdr.2021.82

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© The Author(s) 2021.

© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Cancer stem cells within a colorectal cancer tissue and drug resistance or drug sensitive phenotype. Tumorigenic cells in colon cancer existed as a high-density CD133⁺ population. Small population of CD133⁺ cells that are tumorigenic and drug resistant when subcutaneously implanted in immunodeficient mice reproduce the original tumor properties. In contrast, CD133^- cells do not develop tumors and show drug sensitive phenotype. CSC: Cancer stem cell.