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. 2019 Sep 19;2(3):399–418. doi: 10.20517/cdr.2019.51

Table 1.

Possible roles of piRNAs

piRNAs Functions Ref.
ncRNAs bind to PIWI subfamily Argonaute proteins Epigenetic changes in germ cell lines [61,63-66]
piRNA/PIWI complex Transposon silencing heterochromatin modification [67,68]
piRNAs DNA methylation of transposons and specific genes [69,70]
Degradation of retrotransposon- linked mRNA [71]

piRNA: p-element induced Wimpy testis RNA; mRNA: messenger RNA; ncRNAs: non-coding RNAs