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. 2022 Mar 25;13:809086. doi: 10.3389/fmicb.2022.809086

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Copyright © 2022 Wang, He, Liu, Deng, Fan and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of sodium humate on the intestinal permeability in jejunum and colon of ETEC K88-infected mice. Representative images of the jejunum (A) and colon (B) stained with PAS (200 μm). Arrow points to goblet cell; black bars indicate mucus layer thickness. The number of goblet cells per microscopic field and the mucus layer thickness in the jejunum (C,D) and colon (E,F) of mice. The relative mRNA expression of mucin-1, mucin-2, and mucin-3 in the jejunum (G) and colon (H) of mice. (I) The concentrations of serum DAO, D-lac, and LPS. All of the data are expressed as the mean ± SEM. Different superscript lowercase letters within each group indicate significantly different (P < 0.05).