Table 1.

Effects of DIM on miRNA expression in tumors

Tumor	miRNA	miRNA regulation	Targets
Prostate cancer	let-7	up	EZH2
	miR-34a	up	Notch-1, AR
	miR-150-5p	up	Ahr
	miR-92a	down	RANKL
Breast cancer	miR-200	up	FoxM1
	miR-212/132 cluster	up	Sox4
	miR-21	up	Cdc25A
Pancreatic cancer	let-7b/c/d/e	up	ZEB-1, E-cadherin
	miR-200b/c	up	ZEB-1, E-cadherin
	miR-146a	up	MTA2, NF-κB, IRAK1, EGFR
	miR-221	down	PTEN, PUMA, p27, p57

DIM: 3,3’-diindolylmethane; NF-κB: nuclear factor κB; EGFR: endothelial growth factor receptor