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(A-C) Linear models: Addenbrooke's Cognitive Assessment–Revised (ACE-R) associations at (A) baseline, (B) 1 year, and (C) 3 years. (D) Mixed-effects model: intraindividual changing ACE-R associations between baseline and 1 year. Note that we used 1-year white matter hyperintensity (WMH) volumes in panel C. NART = National Adult Reading Test; VRF = vascular risk factor.
