Table 2.
Pathological characteristics of 105 KSHV/HHV-8-positive PEL samples.
| Samples used for the diagnosis | Number (%) |
|---|---|
| Effusion cytology | 93 (88.7) |
| Lymph node fine-needle aspirate | 1 (0.9) |
| Serous membrane biopsy | 2 (1.9) |
| Unspecified | 9 (8.6) |
|
| |
| Immunophenotype | |
| CD20 negative | 78/86 (90.7) |
| CD3 negative | 67/73 (91.8) |
| CD138 positive | 46/63 (73.0) |
| CD38 positive | 24/25 (96.0) |
| CD30 positive | 55/71 (77.5) |
| EMA positive | 23/26 (95.6) |
| LANA-1 positive | 67/67 (100.0) |
| EBV-LMP-1 negative | 22/22 (100.0) |
|
| |
| B/T cell clonality | |
| Monoclonal | 44/50 (88.0) |
| IGH | 26 |
| IGH+IGK | 2 |
| IGH+TRG | 2 |
| IGH+IGK+TRG | 2 |
| IGK | 6 |
| TRG | 4 |
| Unspecified | 2 |
| Polyclonal/no clonal amplification | 6/50 (12.0) |
|
| |
| Virology | |
| KSHV/HHV-8-DNA positive | 46/46 (100.0) |
| EBV-DNA positivea | 10/31 (32.3) |
| EBER-ish positiveb | 13/46 (28.3) |
a
LMP-1 was absent in 4/10 cases tested;
b
No case was tested for LMP-1