Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jun 19;2(2):271–296. doi: 10.20517/cdr.2019.010

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019.

© The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

PMC Copyright notice

Chemical structures of cis- and carboplatin (A). Action of platinium. Cisplatin [Cis-diamminedichloroplatinum (II)] forms intracellular electrophilic water complexes based on the commonly predominant lower chloride concentrations. Due to its high affinity to the bases guanine and adenine, it forms chelates and inhibits DNA expression. Crosslinks of the DNA single and double strands are formed by platination with a disorder of template function and cell division. Carboplatin [Cis-Diamin (1,1cyclobutandicarboxylo)-platinium] has an equivalent mechanism of action. Chelation and cross-linking of the single and double-stranded DNA inhibit DNA synthesis and transcription triggering apoptosis (B)