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. 2022 Jan 21;64(1):3–12. doi: 10.4103/indianjpsychiatry.indianjpsychiatry_104_21

Table 1.

Summary of genetic variants associated in glia-related genes implicated in schizophrenia

Author Symbol Gene name Gene annotation Polymorphism Regulation SCZ HC Subgroup Region Ethnic group/race
Sims et al., 2009[15] OLIG2 Oligodendrocyte transcription factor 2 Intergenic rs762237 and rs2834072A Putative↓ 1088 1286 LOAD with psychotic symptoms United Kingdom Caucasian
Maeno et al., 2007[16] SOX10 SRY-box transcription factor 10 Intron 3 rs139887B ↓ 915 927 SCZ Japan Japanese
Tao et al., 2014[17] ZNF804AE3E4 Zinc finger protein 804A splice variant Intron 2 rs1344706C ↓ 53 90 SCZ United States Caucasian (43%)
African Americans (51%)
Hispanic (6%)
O’Donovan et al., 2008[18] ZNF804A Zinc finger protein 804A Intron 2 rs1344706D - 479 2937 SCZ United Kingdom Presumably Caucasian
Kadasah et al., 2017[19] TNF TNF Intergenic rs1800629B - 84 138 SCZ Saudi Arabia Saudi Arabs
Suchanek-Raif et al., 2017[20] TNFR1 TNF receptor superfamily member 1A Intron 1 rs4149577 and rs1860545C Putative↑ 388 657 SCZ Poland Polish
Pinheiro et al., 2017[21] GSTM1/GSTT1 Glutathione S-transferase mu 1/glutathione S-transferase theta 1 Double-null genotypeE - 54 78 Treatment-resistant schizophrenia Brazil Brazilian
Raffa et al., 2013[22] GSTT1 Glutathione S-transferase theta 1 Null genotypeF - 138 123 SCZ Tunisia Tunisian
Kim et al., 2008[23] HSPA1A Heat shock protein family A (Hsp70) member 1A Exon 2 rs2075799G - 294 157 SCZ South Korea Korean
Kowalczyk et al., 2014[24] HSPA1A Heat shock protein family A (Hsp70) member 1A Exon 1 rs1043618B - 203 243 SCZ Poland Polish
Bozidis et al., 2014[25] HSPA8 Heat shock protein family A (Hsp70) member 8 Intron 1 rs1136141H - 50 50 First-episode SCZ Greece Greeks
Ding et al., 2016[26] RGS4 Regulator of G protein signaling 4 Intergenic rs10917670, rs2661347, rs951436, and rs2661319C ↓ 35 35 SCZ United States Caucasian (97.14%)
Native Americans (1.42%)
Hispanic (1.42%)

AMassarray; BPolymerase chain reaction-restriction fragment length polymorphism; CTaqMan assay; DAffymetrix GeneChip 500K mapping array; EReal-time polymerase chain reaction (SYBR green); FPolymerase chain reaction; GPyrosequencing; HAmplification refractory mutation system; SCZ – Schizophrenia; HC – Healthy controls; LOAD – Late-onset Alzheimer’s disease; ↑ – Increased; ↓ – Decreased; - – No reported; TNF – Tumor necrosis factor, SYBR: SYBR green (green fluorescent cyanine dye)