Table 3.
Summary of glia-related genes differentially methylated sites in epigenome-wide association studies in schizophrenia
Author | Symbol | Gene name | Gene annotation | CpG site/position | SCZ | HC | Subgroup | Tissue | Region | Ethnic group/race |
---|---|---|---|---|---|---|---|---|---|---|
Wockner et al., 2014[32] | SOX10 | SRY-box transcription factor 10 | 5’UTR; Exon 1 | cg23109891 and cg06614002 | 23 | 24 | SCZ | FCA | United States | Undeterminate |
ZNF804A | Zinc finger protein 804A | Body | ch. 2.3731798R | |||||||
Lee and Huang, 2016[33] | GNA13 | G protein subunit alpha 13 | Promoter | - | 191 | 335 | SCZ | DLPFC (BA46/9)A | United States | Presumably Caucasian |
van Eijk et al., 2015[34] | HLA-C | Major histocompatibility complex, class I, C | Intron 4 | cg16097079 | 260 | 250 | SCZ | PBCB | United States | Undeterminate |
Kinoshita et al., 2013[35] | GFRA2 | GDNF family receptor alpha 2 | Intron 1 | cg22276619 | 24 | 23 | Medication-free SCZ | PBCA | Japan | Japanese |
HDAC4 | Histone deacetylase 4 | Promoter | cg15142485 | |||||||
PCM1 | Pericentriolar material 1 | cg25884094 | ||||||||
CD244 | CD244 molecule | cg11939496 | ||||||||
FAM173A | Adenine nucleotide translocase lysine methyltransferase | Intron 2 | cg09830866 | |||||||
MPG | N-methylpurine DNA glycosylase | Exon 1 | cg16003913 | |||||||
Hannon et al., 2016[36] | DDO | D-aspartate oxidase | Intron 2 | cg14038731 | 414 | 433 | SCZ | PBCA | United Kingdom | Presumably Caucasian |
FAM126A | Family with sequence similarity 126 member A | Promoter region | cg10311104 | |||||||
IL15 | Interleukin 15 | Intron 3 | cg11418177 | |||||||
SIK3 | SIK family kinase 3 | Intron 1 | cg23684410 | |||||||
TNFAIP8 | TNF alpha induced protein 8 | Intron 1 | cg03665078 |
AInfinium humanmethylation450 BeadChip Kit (Illumina); BInfinium humanmethylation27 BeadChip Kit (Illumina). SCZ – Schizophrenia; HC – Healthy controls; DLPFC – Dorsolateral prefrontal cortex; FC – Frontal cortex; PBC – Peripheral blood cells