Skip to main content
. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Crit Rev Biochem Mol Biol. 2021 Jun 20;56(5):441–454. doi: 10.1080/10409238.2021.1925218

Table 1.

Core proteins involved in the DNA damage and replication checkpoint pathways in budding yeast and human.

PIKK
 Activator
 Mediator
 Effector kinase
human yeast Sensor human yeast human yeast human yeast
ATR-ATRIP Mec1-Ddc2 RPA-ssDNA TopBP1

ETAA1		 Dpb11
9-1-1
Dna2		 Claspin
53BP1
Mdc1		 Mrc1
Rad9		 Chk1 Rad53
ATM Tel1 dsDNA break MRN MRX CtIP. Sae2 Chk2 Rad53
Chk1