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Comparison of subtracted IFN-γ responses using QFN SARS-CoV-2 antigen specific to CD4+ T cells (Ag 1) and CD4+ plus CD8+ T cells (Ag 2) in (a) heterologous CV-AZ vaccines and (b) heterologous AZ-CV vaccines at pre-dose 2 and post-dose 2. A two-tailed pair-matched comparison was performed using the Wilcoxon signed-rank test to analyze the significant differences. ** indicated p< .001.
