TABLE 1.

Pharmacokinetic parameters describing the time course of concentrations of ciprofloxacin in plasma and compartments of the eye^a

Compartment and parameterb	Initial estimate	Population mean	Coefficient of variationc	Distribution
Aqueous
Vc (liters)	175	174	4	Normal
ka (h−1)	1.99	2.06	39	Normal
t1/2a (h)	0.35	0.34
kel (h−1)	0.17	0.13	44	Normal
t1/2el (h)	4.1	5.3
kpa · Vc/Va (h−1)	0.052	0.045	14	Log-normal
kap (h−1)	0.22	0.2	34	Log-normal
t1/2ap (h)	3.2	3.5
K	0.24	0.23
Vitreous
Vc (liters)	175	171	4	Normal
ka (h−1)	1.99	2.18	39	Normal
t1/2a (h)	0.35	0.32
kel (h−1)	0.17	0.14	39	Normal
t1/2el (h)	4.1	4.9
kpv · Vc/Vvit (h−1)	0.016	0.022	14	Log-normal
kvp (h−1)	0.054	0.13	34	Log-normal
t1/2vp (h)	13	5.3
K	0.3	0.17

^aHalf-lives corresponding to the rate constants of the model are shown. 

^bt_1/2a, half-life of absorption; t_1/2el, half-life of elimination; t_1/2ap, half-life of loss from the aqueous; t_1/2vp, half-life of loss from the vitreous. The other abbreviations are defined in the text. 

^cIntersubject variability expressed as percent coefficient of variation of the population.