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. 2022 Apr 8;8(14):eabh2445. doi: 10.1126/sciadv.abh2445

Fig. 2. FGF signaling is enriched in NPC.

Fig. 2.

(A) Volcano plot of early gene expression changes in NPC showing differentially expressed genes between normal-adjacent epithelium (n = 14 tumors) and normal nasopharyngeal epithelium samples (n = 5 controls). (B) Gene expression of SPRY1 and SPRY2 across the normal tumor spectrum (n = 171 libraries). (C) Immunohistochemistry of SPRY1 in normal nasopharyngeal epithelium and NPC tumor samples. (D) Expression of FGF1 and FGF2 across the normal tumor spectrum (n = 171 libraries) **P-adj = 0.00326; *P-adj = 0.0158. (E) FGF2 RNA ISH in normal nasopharyngeal epithelium and NPC tumor specimens.