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. 2022 Apr 8;8(14):eabl4370. doi: 10.1126/sciadv.abl4370

Fig. 5. Effect of drug panel on ROS in fibroblasts and CMs.

Fig. 5.

Efficacy of a panel of seven drugs—coenzyme Q10 (Ubi), ALA, Toco, Cys, Rapa, Elam, and Ribo—was evaluated by determining the ability of individual drugs to scavenge ROS in iPSC-derived fibroblasts and CMs. (A) Clustered heatmap for dosage analyses of different drugs. Each row represents data for a specific drug dose, and each set of columns represents data from different cells (fibroblasts and CMs) from healthy control, LS, and ECHS1 patients. All values are represented as ratio of ROS scavenging with drug: baseline. Color representation: green is higher, and red is lower/no ROS scavenging. (B) Drug doses with significant ROS scavenging in fibroblasts (n = 3). (C) Drug doses with significant ROS scavenging in CMs (n = 3). The “n” is representative of the biological replicates and was analyzed by one-way analysis of variance (ANOVA). The data are representative of three independent experiments. Data are represented as means ± SD; *P < 0.05 in comparison to control.