FIGURE 1.

Characteristics of m⁶A methylation in RA PBMCs. (A) Recognition of the top consensus motif from m⁶A peaks determined in PBMCs from the RA and Con groups. (B) Number of m⁶A peaks recognized by m⁶A-seq in the RA and Con groups. (C) Summary of the m⁶A-altered genes identified using m⁶A-seq. (D) Distribution patterns of m⁶A peaks in various chromosomes. (E) m⁶A modification distribution in different gene contexts. (F) Accumulation of m⁶A peaks across transcripts fallen into5′-UTR, CDS, and 3′-UTR. (G) Recognition of the abundance of hypermethylated and hypomethylated m⁶A peaks in the RA PBMCs relative to that of the Con group. m⁶A, N ⁶ -methyladenosine; RA, rheumatoid arthritis; PBMCs, peripheral blood mononuclear cells; and Con, control group.