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. 2022 Mar 25;13:843358. doi: 10.3389/fphar.2022.843358

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Copyright © 2022 Fan, Liu, Gu, Zhang, Ye, Xi, Xia, Wang, Wang, Wang, Xu and Xiao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Conjoint analysis of the MeRIP-seq and RNA-seq data. (A) Distribution of genes with a great variation in both the m⁶A modification and mRNA levels in the PBMCs of RA relative to that of Con. (B) GO enrichment exploration of genes with great variation in both the m⁶A modification and mRNA levels. (C) KEGG subclass of genes with great variation in both the m⁶A modification and mRNA levels. (D) KEGG pathway enrichments of differentially expressed genes at both the m⁶A modification and mRNA levels. PBMCs, peripheral blood mononuclear cells; RA, rheumatoid arthritis; Con, control group; GO, Gene Ontology; m⁶A, N⁶-methyladenosine; and KEGG, Kyoto Encyclopedia of Genes and Genomes.