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. 2022 Mar 25;13:843358. doi: 10.3389/fphar.2022.843358

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Copyright © 2022 Fan, Liu, Gu, Zhang, Ye, Xi, Xia, Wang, Wang, Wang, Xu and Xiao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Potential target analysis of TP. (A) Network analysis between genes with great variation in both the m⁶A modification and mRNA levels and target proteins of TP. (B–E) Gene expression of IGF2BP3 in synovial tissue samples of GEO datasets. (F) Molecular docking of IGF2BP3 and TP. In the picture on the right, thick sticks represent the TP molecule, and thin lines represent residues in the protein binding site. (G,H) mRNA expression of IGF2BP3 in PBMCs and MH7A. *p < 0.05, ** p < 0.01. TP, triptolide; IGF2BP3, insulin-like growth factor 2 mRNA-binding protein 3; GEO, Gene Expression Omnibus; and PBMCs, peripheral blood mononuclear cells.