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. 2022 Mar 3;132(4):984–994. doi: 10.1152/japplphysiol.00428.2021

Figure 3.

Figure 3.

The influence of muscle inflammation susceptibility (MuIS) status on gene expression and muscle integrity. A: inflammatory transcript receptor expression following initial dichotomization combining tumor necrosis factor alpha receptor (TNF-αR), fibroblast growth factor-inducible 14 (Fn14), and interleukin-6 receptor (IL-6R) that resulted in n = 56 MuIS− and n = 14 MuIS+. B: waterfall plot illustrating the inflection point between MuIS+ and MuIS− status using TNF-αR expression to cluster resulting in n = 46 MuIS− and n = 24 MuIS+ participants. C: expression of proinflammatory receptors comparing MuIS+ and MuIS− status, as dichotomized based on TNF-αR expression. D: proinflammatory ligands comparing MuIS+ and MuIS− status. E: markers of skeletal muscle catabolism; E3 ubiquitin ligases comparing MuIS+ and MuIS− status. F: percent skeletal muscle fibrosis across MuIS+ and MuIS− status. Boxplots = median (solid line), mean (square), box-ends = 1st and 3rd quartile, whiskers = ±1.5 interquartile range. *Significant P < 0.05. #Trend P < 0.1.