Table 1.
Summary statistics for patient groups
| Features | Control | LVH | HFpEF |
|---|---|---|---|
| Patients, n | 277 | 143 | 60 |
| Females, % | 71.0 | 55.3 | 61.0 |
| African American, % | 19.8 | 40.1 | 36.8 |
| Age, yr | 55.97 (13.66) | 60.32 (11.68) | 66.30 (11.81) |
| Height, cm | 167.03 (11.65) | 169.82 (10.77) | 168.67 (9.55) |
| Weight, kg | 77.98 (19.13) | 90.64 (22.09) | 92.95 (24.07) |
| Body surface area, m2 | 1.89 (0.25) | 2.06 (0.29) | 2.07 (0.29) |
| Systolic BP, mmHg | 127.44 (12.64) | 134.75 (10.92) | 139.63 (18.37) |
| Diastolic BP, mmHg | 75.41 (7.26) | 79.56 (8.13) | 76.88 (9.32) |
| Pulse pressure, mmHg | 68.78 (9.84) | 67.25 (10.97) | 68.80 (10.71) |
| Heart rate, beats/min | 52.02 (10.70) | 55.19 (10.67) | 62.75 (16.19) |
| MMP1, ng/mL | 0.76 (0.63) | 0.86 (0.66) | 0.89 (0.73) |
| MMP2, ng/mL | 348.29 (143.61) | 324.52 (144.43) | 418.32 (170.64) |
| MMP3, ng/mL | 10.16 (6.27) | 9.35 (5.04) | 11.38 (5.86) |
| MMP7, ng/mL | 1.57 (1.19) | 1.84 (1.17) | 2.13 (1.38) |
| MMP8, ng/mL | 2.60 (3.56) | 3.29 (3.91) | 1.95 (1.52) |
| MMP9, ng/mL | 101.33 (87.39) | 126.20 (87.32) | 125.08 (67.60) |
| TIMP1, ng/mL | 70.68 (23.32) | 81.94 (25.25) | 84.44 (24.89) |
| TIMP2, ng/mL | 77.61 (14.41) | 83.23 (14.38) | 81.83 (12.95) |
| TIMP3, ng/mL | 7.39 (7.89) | 9.22 (9.54) | 5.62 (6.67) |
| TIMP4, ng/mL | 1.47 (0.65) | 1.46 (0.62) | 1.86 (0.76) |
| PINP, ng/mL | 37.81 (20.04) | 34.24 (22.96) | 40.58 (24.82) |
| PIIINP, ng/mL | 7.18 (1.86) | 7.59 (2.05) | 9.14 (3.19) |
| CITP, ng/mL | 2.87 (1.78) | 3.55 (2.02) | 3.80 (3.19) |
| CT-1, ng/mL 10−3 | 0.05 (0.10) | 0.04 (0.08) | 0.02 (0.04) |
| pro-NT BNP, pg/mL | 87.51 (90.22) | 88.60 (99.51) | 210.67 (253.91) |
| sRAGE, ng/mL | 3.39 (2.47) | 3.06 (2.74) | 2.86 (1.97) |
| OSTEO, ng/mL | 74.05 (31.20) | 85.97 (56.91) | 93.15 (42.15) |
| LVIDd, cm | 4.65 (0.44) | 4.84 (0.50) | 4.80 (0.54) |
| LVIDs, cm | 2.83 (0.38) | 2.93 (0.46) | 2.93 (0.45) |
| EDV, mL | 99.42 (21.76) | 107.13 (25.74) | 110.03 (29.00) |
| EDVi, mL/m2 | 52.83 (10.45) | 52.46 (12.03) | 53.41 (13.46) |
| ESV, mL | 31.85 (10.08) | 34.40 (13.02) | 35.02 (13.11) |
| ESVi, mL/m2 | 16.86 (4.89) | 16.76 (5.96) | 16.86 (6.31) |
| SV, mL | 67.57 (15.13) | 72.72 (18.63) | 75.02 (20.52) |
| PSS, g/cm2 | 53.44 (14.42) | 45.84 (11.97) | 44.67 (12.48) |
| ESS, g/cm2 | 38.96 (10.52) | 33.30 (8.61) | 31.40 (8.98) |
| EDS, g/cm2 | 15.51 (3.91) | 12.54 (3.56) | 16.44 (6.27) |
| EF | 0.68 (0.06) | 0.68 (0.09) | 0.68.(0.07) |
Values are means (SD). BP, blood pressure; CITP, carboxyl-terminal telopeptide of collagen type I; CT-1, cardiotrophin; EDS, end diastolic stress; EDV, LV end-diastolic volume; EDVi, LV end-diastolic volume index; EF, ejection fraction; ESS, end systolic stress; ESV, LV end-systolic volume; ESVi, LV end-systolic volume index; HFpEF, heart failure with preserved ejection fraction; LVH, left ventricular hypertrophy; LVIDd, left ventricular internal diameter end diastole; LVIDs, LV internal diameter end systole; MMP, matrix metalloproteinase; NT-proBNP, NH2-terminal propeptide of brain natriuretic peptide; OSTEO, osteopontin; TIMP, tissue inhibitors of metalloproteinases; PINP, NH2-terminal propeptide of procollagen type I; PIIINP, NH2-terminal propeptide of procollagen type III; PSS, peak systolic stress ; sRAGE, soluble receptor for advanced glycation end products; SV, stroke.