TABLE 1.
Characteristics of the case report studies
| First author | Country | Published time | Median age (years) | Male/female | HIV treatment | Median duration of HIV infection (years) | CD4 count (Cells/mm3) | SARS‐CoV‐2 diagnosis method | COVID−19 treatment | Clinical manifestations | Other comorbidities | Outcomes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Alharthy (53) | Saudi Arabia | Nov 2020 | 40 | F | LPV/r, TMP, SMX | NR | 350 |
PCR, Chest CT |
NR | Fever, Cough, Myalgias, Dyspnea | HSV‐2 | Death |
| Giambenedetto (54) | Italy | Jun 2020 | 75 | M | RPV, FTC, TAF, DRV, COBI | 23 | 434 |
PCR, Chest CT |
HCQ, AZI, PI, LMWH | Fever, Diarrhea, Cough, Dyspnea | HTN, HBV | Recovery |
| Bertolini (55) | Argentina | Aug 2020 | 43 | M | TDF, FTC, DTG | NR | 163 |
Chest CT RT‐PCR |
LPV/r, HCQ |
Cough, Dyspnea, Fever Night Sweats, Abdominal pain, Diarrhea |
Disseminated histoplasmosis | Recovery |
| Basso (56) | Southern Brazil | Oct 2020 | 43 | F | TDF, 3TC, ATV/r | 21 | 353 |
Chest CT RT‐PCR |
NR | Disorientation, Cough, Dyspnea, Fever | Disseminated histoplasmosis | Recovery |
| Bessa (57) | Brazil | Oct 2020 | 56 | M | TDF, 3TC, EFV | NR | 1,163 |
Chest CT RT‐PCR |
CRO, CLR | Dyspnea, Asthenia | Ischemic stroke, DM | Recovery |
| Elhadi (58) | Libya | Aug 2020 | 86 | F | ZDV | NR | NR |
RT‐PCR Chest CT |
AMX Clavulanate Pred Mucolytic syrup |
Cough, Fever | T2DM | Death |
| Nakamoto (59) | Japan | Jan 2021 | 28 | M | NR | NR | 194 |
RT‐PCR Chest CT |
HCQ | NR | HBV | NR |
| Khaba (60) | South Africa | Sep 2020 | 19 | M | NR | NR | 17 |
RT‐PCR Chest CT |
CRO, TMP‐SMZ, HCQ, AZI, Enoxaparin | Weakness, Fatigue, Cough, SOB | NR | Death |
| Chiappe‐Gonzalez (61) | South America | Aug 2020 | 38 | M | TDF‐DF, FTC, ATV/r | NR | 438 |
RT‐PCR Chest CT |
Corticosteroids | Weakness, Sore throat, Cough, Dyspnea, Diarrhea | Intra ventricular cryptococcoma | Death |
| Cipolat (62) | Brazil | Aug 2020 | 63 | F | TDF, 3TC, DTG | 15 | 426 |
RT‐PCR Chest CT |
AMX/clavulanate, HCQ, AZI | Myalgia, Inappetence, Nausea, Abdominal pain, Diarrhea, Hyposmia, Hypogeusia, Cough, Dyspnea | NR | Recovery |
| Foster (63) | US | Sep 2020 | 40 | M | LPV, RTV | NR | NR | Chest CT | HCQ, AZI | Fatigue, Cough, Dyspnea, Myalgias, Fever, Chills | NR | Recovery |
| Mahmood (64) | USA | Jul 2020 | 54 | M | FTC‐TDF, Nucleotide reverse transcriptase inhibitor, DTG, Integrase Inhibitor | 29 | 266 |
RT‐PCR Chest CT |
HCQ, Cefuroxime | Fever, Myalgia, Cough, Dyspnea | CHD, CABG, T2DM, KSL, VAD | Recovery |
| Menghua (65) | China | Jul 2020 | 49 | F | EFV, 3TC | 8 | 224 |
RT‐PCR Chest CT |
CRO, Interferon, Atomization, Ribavirin, Abidol |
Fatigue, Fever Pharyngeal pain, Chills |
NR | Recovery |
| Zhao (66) | China | Oct 2020 | 38 | 1 M | 3TC, TDF, EFV, LPV, RTV | 4 | 275 |
RT‐PCR Chest CT |
NR | Fever, Muscle aches | HCV | Recovery |
| Baluku (67) | Uganda | Nov 2020 | 34 | F | TDF, 3TC, EFV | 5 | 965 | RT‐PCR | HCQ, AZI, Paracetamol | Headache, Chest pain, Diarrhea, Anorexia, Fatigue | NR | Recovery |
| Tian (68) | China | Jul 2020 | 24 | M | LPV/r, TDF, 3TC, EFV | 2 | 552 |
RT‐PCR Chest CT |
Ibuprofen, Cefotaxime, Cephalosporin | Fever | NR | Recovery |
| Pujari (69) | India | Jul 2020 | 57 | M | TAF, FTC, DTG, TMP‐SMX | NR | 19 |
RT‐PCR Chest CT |
TDF, 3TC, EFV | Fever, Cough | MTB, HTN, Anemia | Recovery |
| Choy (70) | Singapore | Dec 2020 | 48 | F | NR | NR | 20 |
RT‐PCR Chest CT |
Remdesivir, Corticosteroids |
Cough, SOB, Diarrhea |
PJP Salmonella enteritidis |
Recovery |
| Muller (71) | Austria | May 2020 | 55 | M |
FTC, TDF Alafenamide, RPV |
35 | 820 |
RT‐PCR Chest CT |
Ampicillin/Sulbactam | Fatigue, Fever, Cough, Tachycardia | HCV, liver Transplantation, Liver cirrhosis, HCC | Recovery |
| Martins (72) | Portugal | Jan 2021 | 34 | 1 M | TAF | NR | 77 |
RT‐PCR Chest CT |
Cotrimoxazole, lvx Prednisolone |
Fever, Cough, Bloody sputum, Anterior chest pain, Dyspnea. | Asthenia, Anorexia, Dysphagia, MSSA, PJP | Recovery |
| Bouare (73) | Morocco | Jul 2020 | 32 | F | NR | NR | 32 |
RT‐PCR Chest CT |
Chloroquine, AZI, Rifampin | Fever, Cough, Headache, Myalgia | MTB | NR |
| d’Ettorre G (74) | Italy | July 2020 | 52 | 1F | DRV,COBI | NR | 242 |
RT‐PCR Chest CT |
HCQ | Fever | NR | Recovery |
| Sue (75) | China | 30 Jan 2020 | 32 | M | ZDV, 3TC, EFV | 12 years | 294 | Chest CT | Piperacillin/TazObactam, lvx, OSE, LPV/r, Abidol | Fever, Dizziness, Cough | NR | Recovery |
| Chen J (76) | China | Oct 2020 | 24 | 1 M | TDF, 3TC, Favirenz | 2 years | NR |
RT‐PCR Chest CT |
LPV/r | Fever, Cough | NR | Recovery |
| Tabrizian P (77) | USA | Nov 2020 | 57 | 1F | Atazanavir, FTC‐TDF, Alafenamide, RTV | 24 | NR |
RT‐PCR Antibody testing Chest CT |
NR | Dyspnea, Cough, Malaise | HCV, HCC | Recovery |
| Farinacci (78) | Italy | Apr 2021 | 59 | 1 M | NR | 30 years | 10 |
RT‐PCR Chest CT |
HCQ, Enoxaparin | Fever, Dyspnea | NR | Death |
| Ji‐Yeon Kim (79) | Korea | Sep 2020 | 29 | 1 M | Genvoya, EVG, COBI, FTC, TDF | NR | 555 |
RT‐PCR Chest CT |
HCQ | Sore throat, Cough, loss of taste and smell, Chill, Myalgia, Rhinorrhea | NR | Recovery |
| Coleman H (80) | UK | Apr 2020 | 55 | 1 M | FTC/TDF, Disoproxil, RAL | NR | 422 |
RT‐PCR Chest CT |
NR | Fever, Cough, Hypoxia | PJP, Asthma | Recovery |
| Parker (81) | South Africa | Jun 2020 | 41 | 1 M | TDF, FTC, EFV | 4 years | 78 | Chest CT | NR | Fever, Cough, Myalgia, Diarrhea, Dyspnea | PCP, TB | Recovery |
Abbreviations: LPV/r, lopinavir/ritonavir; TMP, Trimethoprim; SMX, Sulfamethoxazole; TMP‐SMZ, Trimethoprim/sulfamethoxazole; RPV, Rilpivirine; FTC, Emtricitabine; TAF, Tenofovir alafenamide; DRV, darunavir; COBI, Cobicistat; TDF, tenofovir disoproxil fumarate; DTG, Dolutegravir; 3TC, Lamivudine; ATV/r, atazanavir/ritonavir; EFV, Efavirenz; ZDV, Zidovudine; LPV, Lopinavir; RTV, Ritonavir; EFV, Efavirenz; RAL, Raltegravir; HCQ, Hydroxychloroquine; AZI, Azithromycin; LMWH, low molecular weight heparin; CRO, Ceftriaxone; CLR, Clarithromycin; HSV‐2, Herpes simplex virus‐2; HTN, Hypertension; HBV, Hepatitis B; T2DM, Type 2 diabetes; CHD, Coronary heart disease; CABG, coronary artery bypass grafting; KS, Kaposi's sarcoma; LVAD, A left ventricular assist device; PJP or PCP, Pneumocystis jirovecii pneumonia; MSSA, Methicillin‐susceptible Staphylococcus aureus.