Table 2.
Comparison of collected and infused CD34 + cells and hematopoietic recovery between the first auto-HCT(s) and salvage auto-HCT.
| First auto-HCT | Second auto-HCT (n = 46) | Salvage auto-HCT (n = 305) | p* | p** | |
|---|---|---|---|---|---|
| (n = 305) | |||||
| Total collected CD34+cells, x106/kg | |||||
| Median, range | 4.81 (1.63–38.4) | not performed | 3.39 (0.24–16) | <0.001 | NA |
| Missing | 163 (53%) | not performed | 175 (57.4%) | ||
| Total infused CD34 + cells, x106/ kg | |||||
| Median, range | 4.05 (1.37–43.2) | 4.90 (1.93–24.8) | 2.92 (1.07–24.5) | <0.001 | <0.001 |
| Missing | 70 (23%) | 16 (35%) | 52 (17%) | ||
| Hematopoietic recovery; median, IQR (days) | |||||
| ANC > 0.5 × 109/L | 12 (11–14) | 11 (10–13) | 12 (11–14) | 0.3 | 0.02 |
| PLT > 20 × 109/L | 12 (11–15) | 11 (10–12) | 13 (11–16) | 0.08 | <0.001 |
| PLT > 50 × 109/L | 16 (13–21) | 14 (12–18) | 20 (14–34) | <0.001 | <0.001 |
p* - comparison between the first auto-HCT and salvage auto-HCT.
p** - comparison between the second auto-HCT and salvage auto-HCT.
P-values for the comparison of collected and infused CD34+ cells between transplantations were obtained using the F-test from an anova on the linear mixed effect model results. Total number of CD34+ cells were log transformed in the models.
P-values for the comparison of hematopoietic recovery between transplantations were obtained using chi2-tests in Cox proportional hazard frailty models.
NA–not applicable, ANC-absolute neutrophil count, PLT–platelets.