Table 2.
PK-PD parameters (EPM Cmax and EPM AUClast vs efficacy relationships) of EPM treatment against Trichostrongylus colubriformis following a single EPM pour-on administration of a topical 5-mg/mL EPM product at 1 mg/kg to a mixed population of growing male castrated and lactating female dairy breed goats (Studies 1, 2, 3, and 4; n = 34) and lactating female dairy breed goats only (Study 1; n = 10)
| PK-PD parameter | Goat population analyzed | Cmax (ng/mL) | AUClast (day*ng/mL) |
|---|---|---|---|
| Emax (%) | Pooled lactating female + male castrated growing dairy breed goats | 92.1 ± 2.84 | 99.6 ± 4.94 |
| Lactating female dairy breed goats | 92.6 ± 6.95 | 101 ± 13.1 | |
| EC50/50% efficacy | Pooled lactating female + male castrated growing dairy breed goats | 1.92 ± 0.09 | 10.9 ± 0.83 |
| Lactating female dairy breed goats | 2.09 ± 0.17 | 11.5 ± 1.77 | |
| EC90/90% efficacy | Pooled lactating female + male castrated growing dairy breed goats | 2.43 ± 0.11 | 21.1 ± 1.60 |
| Lactating female dairy breed goats ats | 3.50 ± 0.29 | 25.4 ± 3.89 | |
| Gamma | Pooled lactating female + male castrated growing dairy breed goats | 9.19 ± 3.65 | 3.35 ± 0.72 |
| Lactating female dairy breed goats | 4.26 ± 1.74 | 2.78 ± 0.90 |