Figure 1.

Derivation of myocardial and LGE volumes of interest. Panel A is a 4-chamber view with LGE showing typical myocardial nulling difficulties in a patient with TTR cardiac amyloidosis. The standardized 3 × 15 mm green cylindrical VOI is placed in the septum at the mid-ventricular level. Panel B shows the fused PET/MR with high uptake in the septal and lateral wall of the left ventricle and free wall of the right ventricle (VOI TBR_MEAN inset). Panel C shows the LGE image in the short axis with extensive diffuse LGE affecting most of the myocardium with the corresponding short axis view of the septal VOI. Panel D shows the fused PET/MR image of the same slice with diffuse uptake within the left and right ventricular myocardium. Note the intensely high uptake within the most diseased myocardial segment (within the septal VOI) and the difference in TBR_MEAN compared to panel B