Fig. 4.

Lats1 gene expression in response to physiological and pathological factors in skeletal muscle. (a) LATS1 expression in quadriceps muscle biopsy samples of healthy and DMD patients (Haslett et al., 2003). (b) Relative mRNA expression of Lats1 in synergist ablation-overloaded mouse plantaris muscle (Chaillou et al 2013). (c) Lats1 gene expression in mice tibialis anterior muscle injured with cardiotoxin injection at day 0 up to day 21 (Lukjanenko et al. 2013). (d) Effect of human endurance and resistance (strength) exercise on the expression of LATS1 in the vastus lateralis 2.5 h and 5 h after exercise (Vissing and Schjerling, 2014). The circles indicate individual data points. (e–f) Meta-analysis of Lats1 expression in response to (e) acute aerobic and (f) acute resistance exercise (http://www.metamex.eu/) (Pillon et al., 2020). Muscle Biopsies were collected at 0 h up to 96 h after exercise. The fold-change (log2) is represented by a square and the 95% confidence intervals are represented by horizontal lines. LogFC, Fold-change (log2); FDR, false discovery rate; n, sample size; A.U, arbitrary units. *P < 0.05